Gene Expression Profiling in Ischemic and Nonischemic Cardiomyopathy

................................................................................................ii Acknowledgments..................................................................................iv List of Tables........................................................................................viii List of Figures........................................................................................ix Chapter 1: Introduction: Microarray analysis in cardiomyopathy..............................1 The current state of heart failure management.............................................2 Microarray analysis.............................................................................3 Gene discovery...............................................................................7 Molecular signature analysis..............................................................11 Research plan...............................................................................14 Chapter 2: Gene expression analysis of ischemic and nonischemic cardiomyopathy: Shared and distinct genes in the development of heart failure.............................................................................18 Introduction.................................................................................19 Methods......................................................................................20 Results.......................................................................................23 Discussion...................................................................................28 Chapter 3: Identification of a gene expression profile that differentiates between ischemic and nonischemic cardiomyopathy...............................58 Introduction..................................................................................59 Methods......................................................................................60